abstract：BACKGROUND:Usefulness of thiopurine and scheduled infliximab combination therapy in non-immunomodulator (IM)-naïve Crohn's disease (CD) patients and the optimal length of dual therapy are still debated. AIMS:To determine proportion of patients developing disease flare requiring rescue therapy and risk factors associat...

journal_title：Digestive diseases and sciences

authors： Fischer M,Campbell SC,Calley CSJ,Helper DJ,Chiorean MV,Fadda HM

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Suppressive activity of recurrence by interferon-free direct-acting antivirals (DAA) is not elucidated after curative treatment of hepatocellular carcinoma (HCC). PATIENTS AND METHODS:A total of 177 patients received DAA after curative manners of HCC: 89 patients underwent DAA therapy after initial HCC trea...

journal_title：Digestive diseases and sciences

authors： Ikeda K,Kawamura Y,Kobayashi M,Kominami Y,Fujiyama S,Sezaki H,Hosaka T,Akuta N,Saitoh S,Suzuki F,Suzuki Y,Arase Y,Kumada H

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Natural language processing is a powerful technique of machine learning capable of maximizing data extraction from complex electronic medical records. METHODS:We utilized this technique to develop algorithms capable of "reading" full-text radiology reports to accurately identify the presence of fatty live...

journal_title：Digestive diseases and sciences

authors： Redman JS,Natarajan Y,Hou JK,Wang J,Hanif M,Feng H,Kramer JR,Desiderio R,Xu H,El-Serag HB,Kanwal F

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Pancreatic leaks occur as a complication of upper gastrointestinal surgery, acute pancreatitis, or abdominal trauma. Pancreatic fistulas and leaks are primarily managed conservatively. Overall, conservative measures are successful in more than half of cases. Whenever conservative treatment is not efficient, ...

journal_title：Digestive diseases and sciences

authors： Mutignani M,Dokas S,Tringali A,Forti E,Pugliese F,Cintolo M,Manta R,Dioscoridi L

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Neuromediators produced by enteric nervous system regulate inflammatory processes via interacting with enteric immune system. Role of γ-aminobutyric acid (GABA), which is also a neuromediator, has been implicated in autoimmune diseases like multiple sclerosis, type 1 diabetes, and rheumatoid arthritis, where...

journal_title：Digestive diseases and sciences

authors： Aggarwal S,Ahuja V,Paul J

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Diabetic gastroparesis is a common complication of diabetes mellitus, which mainly affects women. Previous studies have demonstrated that oxidative stress is involved in its onset and development. AIMS:This study evaluated the role of vitamin C on diabetes-associated gastric dysmotility. METHODS:Female rat...

journal_title：Digestive diseases and sciences

authors： Da Silva LM,da Silva RCMVAF,Maria-Ferreira D,Beltrame OC,da Silva-Santos JE,Werner MFP

更新日期：2017-09-01 00:00:00

abstract：AIMS:To determine whether temporary fecal diversion for refractory colonic and/or perianal Crohn's disease can lead to clinical remission and restoration of intestinal continuity after optimization of medical therapy. METHODS:We retrospectively reviewed our prospectively maintained database of patients treated at the ...

journal_title：Digestive diseases and sciences

authors： Bafford AC,Latushko A,Hansraj N,Jambaulikar G,Ghazi LJ

更新日期：2017-08-01 00:00:00

abstract：:Sirtuins (SIRT), first described as nicotinamide adenine dinucleotide (NAD+)-dependent type III histone deacetylases, are produced by cells to support in the defense against chronic stress conditions such as metabolic syndromes, neurodegeneration, and cancer. SIRT-3 is one of the most studied members of the mitochondr...

journal_title：Digestive diseases and sciences

authors： De Matteis S,Granato AM,Napolitano R,Molinari C,Valgiusti M,Santini D,Foschi FG,Ercolani G,Vespasiani Gentilucci U,Faloppi L,Scartozzi M,Frassineti GL,Casadei Gardini A

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemoradiation reduces local recurrence in locally advanced rectal cancer, and adherence to national and societal recommendations remains unknown. OBJECTIVE:To determine variability in guideline adherence in rectal cancer treatment and investigate whether hospital volume correlated with variabil...

journal_title：Digestive diseases and sciences

authors： Midura EF,Jung AD,Daly MC,Hanseman DJ,Davis BR,Shah SA,Paquette IM

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Data on cyclic vomiting syndrome (CVS) are limited to studies from tertiary care centers. There is a paucity of information about CVS on a national scale. AIM:To study the clinical characteristics, comorbidities, and hospital outcomes in patients hospitalized with CVS using a nationwide database. METHODS:W...

journal_title：Digestive diseases and sciences

authors： Bhandari S,Venkatesan T

更新日期：2017-08-01 00:00:00

abstract：:Management of pancreatic cystic lesions relies on patients' clinical presentation, imaging, and endoscopic ultrasound. Current research in basic science, radiology, and endoscopy is evolving and making progress in this condition which is relatively common in the general population. This review focuses on the recent en...

journal_title：Digestive diseases and sciences

authors： Bartel MJ,Raimondo M

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Defective autophagic machinery, such as that in Crohn's disease patients homozygous for ATG16L1 risk allele, is associated with alteration of resident gut bacterial communities. However, whether or not host autophagy responds to changes in the resident gut microbial community is not known. Here, we investiga...

journal_title：Digestive diseases and sciences

authors： Singh SB,Wilson M,Ritz N,Lin HC

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND AND AIM:Upper gastrointestinal (UGI) symptoms are common; however, the role of Helicobacter pylori and gastric corpus atrophy in the generation of these symptoms is controversial. The aim of this study was to determine the risk factors for UGI symptoms in adults in an endemic area of H. pylori infection. ME...

journal_title：Digestive diseases and sciences

authors： Lee SP,Lee SY,Kim JH,Sung IK,Park HS,Shim CS

更新日期：2017-06-01 00:00:00

abstract：:The gut microbiota is a vast ensemble of microorganisms inhabiting the mammalian gastrointestinal tract that can impact physiologic and pathologic processes. However, our understanding of the underlying mechanism for the dynamic interaction between host and gut microbiota is still in its infancy. The highly evolved ep...

journal_title：Digestive diseases and sciences

authors： Ye J,Wu W,Li Y,Li L

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The NIH-sponsored Patient-Reported Outcomes Measurement Information System (PROMIS) Gastrointestinal (GI) Symptoms scales were developed to assess patients' GI symptoms in clinical settings. AIMS:To assess responsiveness to change and provide minimally important difference (MID) estimates for the PROMIS GI ...

journal_title：Digestive diseases and sciences

authors： Khanna D,Hays RD,Shreiner AB,Melmed GY,Chang L,Khanna PP,Bolus R,Whitman C,Paz SH,Hays T,Reise SP,Spiegel B

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Relative adrenal insufficiency (RAI) is frequently observed in patients with cirrhosis. We sought to identify evidence in the literature regarding the impact of RAI on clinical outcomes in cirrhotic patients. METHODS:We conducted a systematic review (SR) and meta-analysis (MA) using the Ovid-MEDLINE, EMBASE...

journal_title：Digestive diseases and sciences

authors： Kim G,Huh JH,Lee KJ,Kim MY,Shim KY,Baik SK

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Procedure-induced bleeding is a major complication after endoscopic intervention. AIMS:The aim of this study was to investigate the risk of endoscopy-related bleeding in patients with chronic hematologic thrombocytopenia. METHODS:We investigated endoscopy-related bleeding in 175 procedures performed on 108...

journal_title：Digestive diseases and sciences

authors： Oh HJ,Park JM,Yoon SB,Lee HH,Lim CH,Kim JS,Cho YK,Lee BI,Cho YS,Choi MG

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Hepatic encephalopathy (HE) is considered reversible regarding mental status but may not be cognitively in single-center studies. AIM:To evaluate persistence of learning impairment in prior HE compared to those who never experienced HE (no-HE) in a multicenter study. METHODS:A total of 174 outpatient cirrh...

journal_title：Digestive diseases and sciences

authors： Nardelli S,Allampati S,Riggio O,Mullen KD,Prakash R,Gioia S,Unser A,White MB,Fagan AC,Wade JB,Farcomeni A,Gavis EA,Bajaj JS

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:It is not known whether transjugular intrahepatic porto-systemic shunt (TIPS) is safe in patients with advanced liver cirrhosis. The aim of our study was to evaluate the impact of TIPS on transplant-free survival in patients with liver cirrhosis and MELD score ≥15. METHODS:All adult patients who underwent T...

journal_title：Digestive diseases and sciences

authors： Ascha M,Hanouneh M,S Ascha M,Zein NN,Sands M,Lopez R,Hanouneh IA

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The impact of prior anti-TNF use on "real-life" outcomes of adalimumab therapy in ulcerative colitis (UC) is not well known. AIM:To compare the influence of prior anti-TNF use on the outcomes of adalimumab maintenance treatment in UC patients. We also assessed the effectiveness of adalimumab dose escalation...

journal_title：Digestive diseases and sciences

authors： Taxonera C,Iglesias E,Muñoz F,Calvo M,Barreiro-de Acosta M,Busquets D,Calvet X,Rodríguez A,Pajares R,Gisbert JP,López-Serrano P,Pérez-Calle JL,Ponferrada Á,De la Coba C,Bermejo F,Chaparro M,Olivares D,Alba C,Fernández

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Intestinal Behcet's disease (BD) is a specific subtype of BD. Effective drug therapy for intestinal BD remains elusive. AIMS:To investigate long-term outcomes and identify predictors of sustained response in intestinal BD patients receiving infliximab (IFX) treatment. METHODS:The medical records were revie...

journal_title：Digestive diseases and sciences

authors： Zou J,Ji DN,Cai JF,Guan JL,Bao ZJ

更新日期：2017-02-01 00:00:00

abstract：:With the growing popularity of propofol mediated deep sedation for upper gastrointestinal (GI) endoscopic procedures, challenges are being felt and appreciated. Research suggests that management of the airway is anything but routine in this setting. Although many studies and meta-analyses have demonstrated the safety ...

journal_title：Digestive diseases and sciences

authors： Goudra B,Singh PM

更新日期：2017-01-01 00:00:00

abstract：:Gastroenterologists are in a unique position to assist women with chronic gastrointestinal disorders in order to optimize their health prior to pregnancy. Women, whether with chronic conditions or not, and their infants are more likely to be healthy when pregnancies are planned. Achieving a planned pregnancy at the id...

journal_title：Digestive diseases and sciences

authors： Sridhar A,Cwiak CA,Kaunitz AM,Allen RH

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Biliary complications (BCs) occur in up to 40% of living donor liver transplant (LDLT) recipients. The aim of this study was to evaluate the efficacy of endoscopic therapy in the management of LDLT-related BCs. METHODS:A retrospective study of 100 LDLT recipients at a single transplant center over ...

journal_title：Digestive diseases and sciences

authors： Elwir S,Thompson J,Amateau SK,Trikudanathan G,Attam R,Hassan M,Kandaswamy R,Pruett T,Lake J,Chinnakotla S,Freeman ML,Arain MA

更新日期：2017-01-01 00:00:00

abstract：INTRODUCTION:Liver transplant recipients often perform liver biopsy (LB), specially in the context of potentially recurring diseases, such as hepatitis C infection. However, the LB has risks of complications, despite being the gold standard. Transient elastography (TE) is a noninvasive method comparable to the LB to ev...

journal_title：Digestive diseases and sciences

authors： Della-Guardia B,Evangelista AS,Felga GE,Marins LV,Salvalaggio PR,Almeida MD

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:There is increased awareness about risks and benefits of using domperidone to treat gastroparesis. AIM:To describe the outcome of treating patients with refractory gastroparesis symptoms with domperidone. METHODS:Domperidone 10 mg QID or TID was prescribed to patients with refractory gastroparesis symptoms...

journal_title：Digestive diseases and sciences

authors： Schey R,Saadi M,Midani D,Roberts AC,Parupalli R,Parkman HP

更新日期：2016-12-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is widely considered to be the hepatic manifestation of the metabolic syndrome and is closely linked to dyslipidemia, obesity, and insulin resistance. Patients with NAFLD have increased mortality when compared to the general population, primarily related to cardiovascular disea...

journal_title：Digestive diseases and sciences

authors： Simon TG,Corey KE,Chung RT,Giugliano R

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma is a major type of liver cancer with poor prognosis. AIM:The aim of the study was to determine the prognostic significance of plasma interleukin-35 level in hepatocellular carcinoma. METHODS:A total of 153 hepatocellular carcinoma patients and 153 healthy controls were enrolled. Bl...

journal_title：Digestive diseases and sciences

authors： Qiu X,Wang X,Song Y,Chen L

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The Child-Turcotte-Pugh (CTP) score is a widely used and validated predictor of long-term survival in cirrhosis. However, the cutpoints for stratifying laboratory variables in CTP have never been validated. OBJECTIVE:The objective of this study was to identify evidence-based cutpoints for the CTP laboratory...

journal_title：Digestive diseases and sciences

authors： Kaplan DE,Dai F,Skanderson M,Aytaman A,Baytarian M,D'Addeo K,Fox R,Hunt K,Knott A,Mehta R,Pedrosa M,Pocha C,Valderrama A,Taddei T,VOCAL Study Group.

更新日期：2016-11-01 00:00:00

abstract：AIM:To investigate whether a diagnostic delay is associated with a poor outcome in Crohn's disease (CD). METHODS:Medical and socioeconomic characteristics as well as medications and need for surgery of consecutive CD adults patients followed in three referral centers were prospectively recorded using an electronic dat...

journal_title：Digestive diseases and sciences

authors： Nahon S,Lahmek P,Paupard T,Lesgourgues B,Chaussade S,Peyrin-Biroulet L,Abitbol V

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is a heterogeneous collection of chronic inflammatory disorders of the digestive tract. Clinical, genetic, and pathological heterogeneity makes it increasingly difficult to translate efficacy studies into real-world practice. Our objective was to develop a comprehensive natur...

journal_title：Digestive diseases and sciences

authors： Anderson AJ,Click B,Ramos-Rivers C,Babichenko D,Koutroubakis IE,Hartman DJ,Hashash JG,Schwartz M,Swoger J,Barrie AM 3rd,Dunn MA,Regueiro M,Binion DG

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder with increasing prevalence. However, epidemiologic data have mostly been acquired from small studies. We sought to describe the epidemiology of EoE in the USA, utilizing a large database. METHODS:We queried a commercial database (Exp...

journal_title：Digestive diseases and sciences

authors： Mansoor E,Cooper GS

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Industrialization has been linked to the etiology of inflammatory bowel disease (IBD). AIM:We investigated the association between air pollution exposure and IBD. METHODS:The European Prospective Investigation into Cancer and Nutrition cohort was used to identify cases with Crohn's disease (CD) (n = 38) an...

journal_title：Digestive diseases and sciences

authors： Opstelten JL,Beelen RMJ,Leenders M,Hoek G,Brunekreef B,van Schaik FDM,Siersema PD,Eriksen KT,Raaschou-Nielsen O,Tjønneland A,Overvad K,Boutron-Ruault MC,Carbonnel F,de Hoogh K,Key TJ,Luben R,Chan SSM,Hart AR,Bueno-de-

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND/AIM:Herbal and dietary supplement (HDS) hepatotoxicity is increasingly being reported in the USA. This case series describes the presenting clinical features and outcomes of seven patients with liver injury attributed to OxyELITE Pro enrolled in the Drug-Induced Liver Injury Network (DILIN) study. METHODS:T...

journal_title：Digestive diseases and sciences

authors： Heidemann LA,Navarro VJ,Ahmad J,Hayashi PH,Stolz A,Kleiner DE,Fontana RJ

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Eosinophilic gastroenteritis (EOGE) is a rare idiopathic disease characterized by eosinophil-predominant inflammation of the stomach and/or intestines. Our aims are to determine the epidemiology, clinical features and outcomes of EOGE cases in a tertiary-care hospital. METHODS:Retrospective cohort study of ...

journal_title：Digestive diseases and sciences

authors： Alhmoud T,Hanson JA,Parasher G

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:IL-1β is a cytokine involved in mediating epithelial barrier dysfunction in the gut. It is known that IL-1β mediates activation of non-muscle myosin light chain kinase in epithelial cells, but the precise mechanism by which epithelial barrier dysfunction is induced by IL-1β is not understood. METHODS AND RE...

journal_title：Digestive diseases and sciences

authors： Haines RJ,Beard RS Jr,Chen L,Eitnier RA,Wu MH

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND AIM:The association between nonalcoholic fatty liver disease (NAFLD) and apolipoprotein C3 gene (APOC3) promoter region single-nucleotide polymorphisms (SNPs) rs2854117 and rs2854116 is controversial. The aim of this study was to investigate the relationship between other polymorphisms of APOC3 and NAFLD...

journal_title：Digestive diseases and sciences

authors： Zhang RN,Zheng RD,Mi YQ,Zhou D,Shen F,Chen GY,Zhu CY,Pan Q,Fan JG

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) is a chronic condition and the most common form of inflammatory bowel disease. The goal of standard treatment is mainly to induce and maintain remission with anti-inflammatory, immunosuppressive agents, and/or colectomy. Fecal microbiota transplantation (FMT) has been used successfull...

journal_title：Digestive diseases and sciences

authors： Tian Z,Liu J,Liao M,Li W,Zou J,Han X,Kuang M,Shen W,Li H

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The relationship between insulin resistance and post-ERCP pancreatitis (PEP) is not known. We aimed to determine the relation between pre-ERCP insulin resistance and risk of PEP, and to evaluate the relationship of insulin resistance with well-established risk factors for PEP. METHODS:Consecutive p...

journal_title：Digestive diseases and sciences

authors： Koksal AR,Boga S,Alkim H,Bayram M,Ergun M,Alkim C

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Although the mortality rates for non-variceal upper gastrointestinal bleeding (NVUGIB) have recently decreased, it remains a significant medical problem. AIM:The main aim of this prospective multicenter database study was to construct a clinically useful predictive scoring system by using our predictors and...

journal_title：Digestive diseases and sciences

authors： Hwang S,Jeon SW,Kwon JG,Lee DW,Ha CY,Cho KB,Jang B,Park JB,Park YS,Daegu-Gyengbuk Gastrointestinal Study Group (DGSG).

更新日期：2016-07-01 00:00:00